Opiate withdrawal symptoms
The early signs, the later ones, the emotional side, and the few symptoms that mean you should get medical help today.
Find treatment near youUpdated October 2026. Sources are linked on this page.
The short answer
- Early symptoms
- Anxiety, aching muscles, sweating, a runny nose, watery eyes, yawning and trouble sleeping.
- Later symptoms
- Stomach cramps, nausea, vomiting, diarrhea, goosebumps and wide pupils.
- Get help now if
- You cannot keep fluids down, you are pregnant, you feel faint or confused, or you are thinking about suicide.
The first signs that withdrawal has started
The early symptoms often arrive quietly. Many people mistake them for a cold coming on, or for nerves.
MedlinePlus lists these as the early symptoms of opioid withdrawal:
- Agitation and anxiety
- Muscle aches
- Watery eyes and a runny nose
- Sweating
- Yawning, over and over
- Trouble falling or staying asleep
With heroin or immediate-release pain pills, this usually begins within a day of the last dose. The withdrawal timeline shows how the days tend to unfold for different opioids.
What comes next as withdrawal builds
After the early phase, the stomach and gut take over. These later symptoms are the ones people dread most.
- Stomach cramps
- Nausea and vomiting
- Diarrhea
- Goosebumps and chills
- Wide (dilated) pupils
The National Institute on Drug Abuse (NIDA) also describes muscle and bone pain, cold flashes and leg movements you cannot control.
Hot and cold flushes are common, so you may be sweating one minute and shivering the next. None of this is pleasant. In a healthy adult, it is the body recalibrating, and it passes.
How strong the symptoms get depends on which opioid you took, how much and for how long. Two people stopping the same drug can have quite different weeks.
Symptoms from fentanyl are the same in kind, though many people find they come on faster.
The emotional side people do not expect
Withdrawal is not only physical. For many people the mental symptoms are harder to sit through than the cramps.
Anxiety and restlessness
You may feel on edge, unable to settle, pacing or shifting in bed. This often starts early and can be at its worst at night.
Low mood
Feeling flat, hopeless or tearful is common during withdrawal and in the weeks after. SAMHSA notes that anxiety, depression and sleep problems can last for weeks or months after opioid withdrawal.
Cravings
Your body knows that one dose would end the misery, and it reminds you constantly. A craving is a symptom, the same as a cramp. It says nothing about your character.
If low mood or cravings carry on after the physical symptoms have gone, read about post-acute withdrawal.
Symptoms that mean get medical help now
Most withdrawal symptoms are miserable without being dangerous. A few are warning signs. Get medical help the same day, or go to an emergency room, if you notice any of these:
- You cannot keep fluids down. Ongoing vomiting and diarrhea can cause dehydration and upset the balance of salts in your body.
- Signs of dehydration. Dizziness when you stand, a very dry mouth, confusion, a racing heart, or passing very little urine.
- Trouble breathing or chest pain. Vomit breathed into the lungs can cause a lung infection.
- You are pregnant. The CDC says quickly stopping opioids in pregnancy is not recommended because of the risk to the pregnancy.
- You have another serious health condition. Withdrawal puts extra strain on a body that is already unwell.
- Thoughts of suicide or self-harm. Call or text 988 at any hour.
Call 911 if someone is not breathing or cannot be woken. That is not withdrawal. It may be an overdose, and it can happen when someone returns to use after their tolerance has dropped. Learn the signs on the overdose risk page.
Why these symptoms are worth treating
People often feel they should tough it out. There is no medal for that, and there is a real cost.
Untreated symptoms are a common reason people go back to opioids partway through. Going back after a few days without is when overdose risk rises, because tolerance has already started to fall.
A prescriber can treat withdrawal directly with buprenorphine or methadone, or ease individual symptoms with medicines such as lofexidine or clonidine. The page on easing withdrawal symptoms explains what each option does.
If you are not sure where to start, SAMHSA’s National Helpline at 1-800-662-4357 gives free, confidential referrals around the clock. You can also search the treatment directory for providers in your state.
For how all the pieces fit together, go back to the main guide to opiate withdrawal.
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Questions people ask us
What does opiate withdrawal feel like?
Most people compare it to a severe flu with anxiety on top. You ache, sweat, shiver, yawn and cannot sleep. Then come stomach cramps, vomiting and diarrhea. Cravings run through all of it. It is very uncomfortable, and for healthy adults it is rarely dangerous in itself.
Is diarrhea during withdrawal dangerous?
It can be if it goes on for days, because you lose fluid and salts. Keep sipping water or other clear fluids. Get medical help if you cannot keep liquids down, feel dizzy or confused, or are passing very little urine. A clinician can treat the diarrhea and replace fluids.
Why can't I sleep during withdrawal?
Insomnia is one of the listed early symptoms of opioid withdrawal, and it often outlasts the others. Restlessness, aching legs and anxiety all make it worse. A prescriber can help with sleep safely. Avoid alcohol or sedatives you were not prescribed, since mixing them with opioids raises overdose risk.
What does withdrawal look like to someone watching?
From the outside you may see sweating, shaking, irritability, a runny nose, vomiting and pacing. The person may seem angry or low. Stay calm, offer fluids, and know the warning signs above. Our page on naloxone explains how to respond to an overdose.
Sources
- MedlinePlus: Opiate and opioid withdrawal
- World Health Organization (NCBI Bookshelf): Clinical guidelines for withdrawal management, chapter 4
- NIDA: What are the long-term effects of heroin use?
- CDC: Treatment of opioid use disorder before, during, and after pregnancy
- SAMHSA: Protracted withdrawal advisory
This page is general information, not medical advice. Talk with a clinician about your own situation.